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dc.contributor.advisorMarín Giraldo, María del Pilar
dc.contributor.authorNarvaez Maldonado, Carlos Fernando
dc.contributor.authorSanchez Sierra, Astrid Carolina
dc.contributor.authorHernández Gómez, Jairo Alonso
dc.date.accessioned2023-01-24T21:22:17Z
dc.date.available2023-01-24T21:22:17Z
dc.date.issued2022
dc.identifier.urihttps://digitk.areandina.edu.co/handle/areandina/4676
dc.description78 páginas : tablas, ilustraciones ; 58 cm.spa
dc.description.abstractLa enfermedad trofoblástica gestacional constituye un conjunto de trastornos del tejido trofoblástico placentario que se derivan de anormalidades en el proceso de fertilización, su incidencia varía ampliamente según la región estudiada y se pueden presentar la mayoría de casos en extremos de edades. Dado la poca frecuencia de la misma no se tiene una gran cantidad de literatura reportada o de estudios prospectivos o ensayos clínicos por lo que se requieren estudios que ayuden a fomentar el desarrollo de nuevas investigaciones que permitan ampliar los conocimientos sobre la enfermedad.spa
dc.description.tableofcontentsConsideraciones generales.-- Pregunta de investigación.-- Objetivo de investigación.-- Justificación.-- Marco referencial.-- Metodología.-- Resultados.-- Conclusiones.-- Recomendaciones.-- Bibliografía.spa
dc.format.extent78 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.publisherBogotá : Fundación Universitaria del Área Andina , 2022spa
dc.rightsEL AUTOR-ESTUDIANTE, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto, la obra es de su exclusiva autoría y tiene la titularidad sobre la misma. PARÁGRAFO: en caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL ESTUDIANTE-AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la Fundación Universitaria del Área Andina actúa como un tercero de buena fe.spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.titleCaracterización de los aspectos clínicos, métodos diagnósticos, manejo y evolución de la enfermedad trofoblástica gestacional en una institución de tercer nivel de Risaralda, 2015-2021spa
dc.typeTrabajo de grado - Especializaciónspa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)spa
dc.subject.armarcMedicina clínica
dc.subject.armarcDiagnóstico
dc.subject.armarcTumores trofoblásticos
dc.contributor.educationalvalidatorMarín Giraldo, María del Pilar
dc.publisher.placePereiraspa
dc.relation.referencesElias KM, Berkowitz RS, Horowitz NS. State-of-the-art workup and initial management of newly diagnosed molar pregnancy and postmolar gestational trophoblastic Neoplasia. Vol. 17, JNCCN Journal of the National Comprehensive Cancer Network. Harborside Press; 2019. p. 1396–401.spa
dc.relation.referencesEiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, et al. Guideline No. 408: Management of Gestational Trophoblastic Diseases. Journal of Obstetrics and Gynaecology Canada. 2021 Jan 1;43(1):91-105.e1.spa
dc.relation.referencesParker VL, Tidy JA. Current management of gestational trophoblastic diseasespa
dc.relation.referencesNgan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, et al. Diagnosis and management of gestational trophoblastic disease: 2021 update. International Journal of Gynecology and Obstetrics. 2021 Oct 1;155(S1):86–93.spa
dc.relation.referencesSantaballa A, García Y, Herrero A, Laínez N, Fuentes J, de Juan A, et al. SEOM clinical guidelines in gestational trophoblastic disease (2017). Clinical and Translational Oncology. 2018 Jan 1;20(1):38–46.spa
dc.relation.referencesHorowitz NS, Eskander RN, Adelman MR, Burke W. Epidemiology, diagnosis, and treatment of gestational trophoblastic disease: A Society of Gynecologic Oncology evidenced-based review and recommendation. Gynecol Oncol [Internet]. 2021;163(3):605–13. Available from: https://www.sciencedirect.com/science/article/pii/S0090825821014219spa
dc.relation.referencesVillegas-Mejía CR, Chacón-Cardona JA, Villegas-Jaramillo M. Enfermedad trofoblástica gestacional en un centro oncológico de Caldas – Colombia durante el periodo 2001 – 2014. Revista Médicas UIS [Internet]. 2017 Dec 1;30(3):39–49. Available from: http://revistas.uis.edu.co/index.php/revistamedicasuis/article/view/7294/7552spa
dc.relation.referencesJoneborg U, Folkvaljon Y, Papadogiannakis N, Lambe M, Marions L. Temporal trends in incidence and outcome of hydatidiform mole: a retrospective cohort study. Acta Oncol (Madr). 2018 Aug 3;57(8):1094–9spa
dc.relation.referencesAurore F, Khadidja B, Ginette R, Ulrike MH, Jean-Christophe T, Frédérique SB, et al. Gestational trophoblastic disease in Switzerland: Retrospective study of the impact of a regional reference centre. Swiss Med Wkly. 2021;151(5–6).spa
dc.relation.referencesDescargues P, Hajri T, Massardier J, Lotz JP, Devouassoux-Shisheboran M, Allias Montmayeur F, et al. Gestational trophoblastic neoplasia after human chorionic gonadotropin normalization in a retrospective cohort of 7761 patients in France. Am J Obstet Gynecol. 2021;225(4):401.e1-401.e9.spa
dc.relation.referencesJauniaux E, Memtsa M, Johns J, Ross JA, Jurkovic D. New insights in the pathophysiology of complete hydatidiform mole. Placenta. 2018;62:28–33.spa
dc.relation.referencesal Wahaibi F, al Ghaithi H, AlShamsi R, Gowri V, al Rawahi T. Gestational Trophoblastic Disease: Prevalence, Management and Follow-Up at a Tertiary Center in Oman—An 11-Year Study. Indian J Gynecol Oncol [Internet]. 2019;17(4):88. Available from: https://doi.org/10.1007/s40944-019-0332-zspa
dc.relation.referencesCoyle C, Short D, Jackson L, Sebire NJ, Kaur B, Harvey R, et al. What is the optimal duration of human chorionic gonadotrophin surveillance following evacuation of a molar pregnancy? A retrospective analysis on over 20,000 consecutive patients. Gynecol Oncol. 2018;148(2):254–7.spa
dc.relation.referencesAlbright BB, Myers ER, Moss HA, Ko EM, Sonalkar S, Havrilesky LJ. Surveillance for gestational trophoblastic neoplasia following molar pregnancy: a cost-effectiveness analysis. Am J Obstet Gynecol. 2021;225(5):513.e1-513.e19spa
dc.relation.referencesHoeijmakers YM, Eysbouts YK, Massuger LFAG, Dandis R, Inthout J, van Trommel NE, et al. Early prediction of post-molar gestational trophoblastic neoplasia and resistance to methotrexate, based on a single serum human chorionic gonadotropin measurement. Gynecol Oncol [Internet]. 2021;163(3):531–7. Available from: https://www.sciencedirect.com/science/article/pii/S0090825821013858spa
dc.relation.referencesLin LH, Maestá I, Braga A, Sun SY, Fushida K, Francisco RPV, et al. Multiple pregnancies with complete mole and coexisting normal fetus in North and South America: A retrospective multicenter cohort and literature review. Gynecol Oncol. 2017;145(1):88–95.spa
dc.relation.referencesUsui H, Qu J, Sato A, Pan Z, Mitsuhashi A, Matsui H, et al. Gestational Trophoblastic Neoplasia From Genetically Confirmed Hydatidiform Moles: Prospective Observational Cohort Study. International Journal of Gynecologic Cancer [Internet]. 2018 Nov 1;28(9):1772. Available from: http://ijgc.bmj.com/content/28/9/1772.abstractspa
dc.relation.referencesZheng XZ, Qin XY, Chen SW, Wang P, Zhan Y, Zhong PP, et al. Heterozygous/dispermic complete mole confers a significantly higher risk for post-molar gestational trophoblastic disease. Modern Pathology. 2020;33(10):1979–88.spa
dc.relation.referencesBraga A, Biscaro A, do Amaral Giordani JM, Viggiano M, Elias KM, Berkowitz RS, et al. Does a human chorionic gonadotropin level of over 20,000 IU/L four weeks after uterine evacuation for complete hydatidiform mole constitute an indication for chemotherapy for gestational trophoblastic neoplasia? European Journal of Obstetrics & Gynecology and Reproductive Biology [Internet]. 2018;223:50–5. Available from: https://www.sciencedirect.com/science/article/pii/S0301211518300496spa
dc.relation.referencesMylvaganam G, Allanson E, Allanson B, Philp S, Pather S, Farrell R, et al. Assessment of current follow-up for complete molar pregnancies: A single centre review. Australian and New Zealand Journal of Obstetrics and Gynaecology. 2021 Apr 1;61(2):213–6.spa
dc.relation.referencesKhosravirad A, Zayeri F, Baghestani AR, Yoosefi M, Bakhtiyari M. Predictive power of human chorionic gonadotropin in post-molar gestational trophoblastic neoplasia: A longitudinal roc analysis. Int J Cancer Manag. 2017;10(9)spa
dc.relation.referencesSubbaiah M, Raj A, Durairaj J, Keepanasseril A. Role of hysteroscopy and ultrasound in early identification of post-molar gestational trophoblastic neoplasia. European Journal of Obstetrics & Gynecology and Reproductive Biology [Internet]. 2020;254:33–7. Available from: https://www.sciencedirect.com/science/article/pii/S0301211520305704spa
dc.relation.referencesAlifrangis C, Seckl MJ. Genetics of gestational trophoblastic neoplasia: An update for the clinician. Vol. 6, Future Oncology. 2010. p. 1915–23.spa
dc.relation.referencesNica A, Bouchard-Fortier G, Covens A. 34 Gestational Trophoblastic Disease Hydatidiform Mole, Nonmetastatic and Metastatic Gestational Trophoblastic Tumor: Diagnosis and Management.spa
dc.relation.referencesLurain JR. Gestational trophoblastic disease I: Epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Vol. 203, American Journal of Obstetrics and Gynecology. Mosby Inc.; 2010. p. 531–9.spa
dc.relation.referencesLin LH, Polizio R, Fushida K, Francisco RPV. Imaging in Gestational Trophoblastic Disease. Vol. 40, Seminars in Ultrasound, CT and MRI. W.B. Saunders; 2019. p. 332–49.spa
dc.relation.referencesLok C, van Trommel N, Massuger L, Golfier F, Seckl M, Abreu MH, et al. Practical clinical guidelines of the EOTTD for treatment and referral of gestational trophoblastic disease. Eur J Cancer. 2020 May 1;130:228–40.spa
dc.relation.referencesAl Wahaibi F, al Ghaithi H, AlShamsi R, Gowri V, al Rawahi T. Gestational Trophoblastic Disease: Prevalence, Management and Follow-Up at a Tertiary Center in Oman—An 11-Year Study. Indian J Gynecol Oncol [Internet]. 2019;17(4):88. Available from: https://doi.org/10.1007/s40944-019-0332-zspa
dc.relation.referencesAlbright BB, Myers ER, Moss HA, Ko EM, Sonalkar S, Havrilesky LJ. Surveillance for gestational trophoblastic neoplasia following molar pregnancy: a cost-effectiveness analysis. Am J Obstet Gynecol. 2021;225(5):513.e1-513.e19.spa
dc.relation.referencesAlifrangis C, Seckl MJ. Genetics of gestational trophoblastic neoplasia: An update for the clinician. Vol. 6, Future Oncology. 2010. p. 1915–23.spa
dc.relation.referencesAurore F, Khadidja B, Ginette R, Ulrike MH, Jean-Christophe T, Frédérique SB, et al. Gestational trophoblastic disease in Switzerland: Retrospective study of the impact of a regional reference centre. Swiss Med Wkly. 2021;151(5–6)spa
dc.relation.references● Braga A, Biscaro A, do Amaral Giordani JM, Viggiano M, Elias KM, Berkowitz RS, et al. Does a human chorionic gonadotropin level of over 20,000 IU/L four weeks after uterine evacuation for complete hydatidiform mole constitute an indication for chemotherapy for gestational trophoblastic neoplasia? European Journal of Obstetrics & Gynecology and Reproductive Biology [Internet]. 2018;223:50–5. Available from: https://www.sciencedirect.com/science/article/pii/S0301211518300496spa
dc.relation.referencesCoyle C, Short D, Jackson L, Sebire NJ, Kaur B, Harvey R, et al. What is the optimal duration of human chorionic gonadotrophin surveillance following evacuation of a molar pregnancy? A retrospective analysis on over 20,000 consecutive patients. Gynecol Oncol. 2018;148(2):254–7.spa
dc.relation.referencesDescargues P, Hajri T, Massardier J, Lotz JP, Devouassoux-Shisheboran M, Allias Montmayeur F, et al. Gestational trophoblastic neoplasia after human chorionic gonadotropin normalization in a retrospective cohort of 7761 patients in France. Am J Obstet Gynecol. 2021;225(4):401.e1-401.e9.spa
dc.relation.referencesEiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, et al. Guideline No. 408: Management of Gestational Trophoblastic Diseases. Journal of Obstetrics and Gynaecology Canada. 2021 Jan 1;43(1):91-105.e1.spa
dc.relation.referencesElias KM, Berkowitz RS, Horowitz NS. State-of-the-art workup and initial management of newly diagnosed molar pregnancy and postmolar gestational trophoblastic Neoplasia. Vol. 17, JNCCN Journal of the National Comprehensive Cancer Network. Harborside Press; 2019. p. 1396–401.spa
dc.relation.referencesHoeijmakers YM, Eysbouts YK, Massuger LFAG, Dandis R, Inthout J, van Trommel NE, et al. Early prediction of post-molar gestational trophoblastic neoplasia and resistance to methotrexate, based on a single serum human chorionic gonadotropin measurement. Gynecol Oncol [Internet]. 2021;163(3):531–7. Available from: https://www.sciencedirect.com/science/article/pii/S0090825821013858spa
dc.relation.referencesHorowitz NS, Eskander RN, Adelman MR, Burke W. Epidemiology, diagnosis, and treatment of gestational trophoblastic disease: A Society of Gynecologic Oncology evidenced-based review and recommendation. Gynecol Oncol [Internet]. 2021;163(3):605–13. Available from: https://www.sciencedirect.com/science/article/pii/S0090825821014219spa
dc.relation.referencesJauniaux E, Memtsa M, Johns J, Ross JA, Jurkovic D. New insights in the pathophysiology of complete hydatidiform mole. Placenta. 2018;62:28–33.spa
dc.relation.referencesJoneborg U, Folkvaljon Y, Papadogiannakis N, Lambe M, Marions L. Temporal trends in incidence and outcome of hydatidiform mole: a retrospective cohort study. Acta Oncol (Madr). 2018 Aug 3;57(8):1094–9.spa
dc.relation.referencesKhosravirad A, Zayeri F, Baghestani AR, Yoosefi M, Bakhtiyari M. Predictive power of human chorionic gonadotropin in post-molar gestational trophoblastic neoplasia: A longitudinal roc analysis. Int J Cancer Manag. 2017;10(9).spa
dc.relation.referencesLin LH, Maestá I, Braga A, Sun SY, Fushida K, Francisco RPV, et al. Multiple pregnancies with complete mole and coexisting normal fetus in North and South America: A retrospective multicenter cohort and literature review. Gynecol Oncol. 2017;145(1):88–95.spa
dc.relation.referencesLin LH, Polizio R, Fushida K, Francisco RPV. Imaging in Gestational Trophoblastic Disease. Vol. 40, Seminars in Ultrasound, CT and MRI. W.B. Saunders; 2019. p. 332–49.spa
dc.relation.referencesLok C, van Trommel N, Massuger L, Golfier F, Seckl M, Abreu MH, et al. Practical clinical guidelines of the EOTTD for treatment and referral of gestational trophoblastic disease. Eur J Cancer. 2020 May 1;130:228–40.spa
dc.relation.referencesLurain JR. Gestational trophoblastic disease I: Epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Vol. 203, American Journal of Obstetrics and Gynecology. Mosby Inc.; 2010. p. 531–9.spa
dc.relation.referencesMylvaganam G, Allanson E, Allanson B, Philp S, Pather S, Farrell R, et al. Assessment of current follow-up for complete molar pregnancies: A single centre review. Australian and New Zealand Journal of Obstetrics and Gynaecology. 2021 Apr 1;61(2):213–6.spa
dc.relation.referencesNgan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, et al. Diagnosis and management of gestational trophoblastic disease: 2021 update. International Journal of Gynecology and Obstetrics. 2021 Oct 1;155(S1):86–93 Nica A, Bouchard-Fortier G, Covens A. 34 Gestational Trophoblastic Disease Hydatidiform Mole, Nonmetastatic and Metastatic Gestational Trophoblastic Tumor: Diagnosis and Managementspa
dc.relation.referencesParker VL, Tidy JA. Current management of gestational trophoblastic disease.spa
dc.relation.referencesSantaballa A, García Y, Herrero A, Laínez N, Fuentes J, de Juan A, et al. SEOM clinical guidelines in gestational trophoblastic disease (2017). Clinical and Translational Oncology. 2018 Jan 1;20(1):38–46.spa
dc.relation.referencesSubbaiah M, Raj A, Durairaj J, Keepanasseril A. Role of hysteroscopy and ultrasound in early identification of post-molar gestational trophoblastic neoplasia. European Journal of Obstetrics & Gynecology and Reproductive Biology [Internet]. 2020;254:33–7. Available from: https://www.sciencedirect.com/science/article/pii/S0301211520305704spa
dc.relation.referencesUsui H, Qu J, Sato A, Pan Z, Mitsuhashi A, Matsui H, et al. Gestational Trophoblastic Neoplasia From Genetically Confirmed Hydatidiform Moles: Prospective Observational Cohort Study. International Journal of Gynecologic Cancer [Internet]. 2018 Nov 1;28(9):1772. Available from: http://ijgc.bmj.com/content/28/9/1772.abstractspa
dc.relation.referencesVillegas-Mejía CR, Chacón-Cardona JA, Villegas-Jaramillo M. Enfermedad trofoblástica gestacional en un centro oncológico de Caldas – Colombia durante el periodo 2001 – 2014. Revista Médicas UIS [Internet]. 2017 Dec 1;30(3):39–49. Available from: http://revistas.uis.edu.co/index.php/revistamedicasuis/article/view/7294/755 2spa
dc.relation.referencesZheng XZ, Qin XY, Chen SW, Wang P, Zhan Y, Zhong PP, et al. Heterozygous/dispermic complete mole confers a significantly higher risk for post-molar gestational trophoblastic disease. Modern Pathology. 2020;33(10):1979–88.spa
dc.rights.accessrightsinfo:eu-repo/semantics/closedAccessspa
dc.type.contentTextspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.description.degreelevelEspecializaciónspa
dc.description.degreenameEspecialista en Epidemiologíaspa
dc.description.programEspecialización en Epidemiologíaspa
dc.publisher.facultyFacultad de Ciencias de la Salud y del Deportespa
dc.relation.indexedLaReferenciaspa


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EL AUTOR-ESTUDIANTE, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto, la obra es de su exclusiva autoría y tiene la titularidad sobre la misma. PARÁGRAFO: en caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL ESTUDIANTE-AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la Fundación Universitaria del Área Andina actúa como un tercero de buena fe.
Excepto si se señala otra cosa, la licencia del ítem se describe como EL AUTOR-ESTUDIANTE, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto, la obra es de su exclusiva autoría y tiene la titularidad sobre la misma. PARÁGRAFO: en caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL ESTUDIANTE-AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la Fundación Universitaria del Área Andina actúa como un tercero de buena fe.